Traveling Pharmacy and Thru-Hiker are totally meaningless in a hig STR Bloodied build.
I mean, with 4 Unyielding armor pieces (and only 1 chameleon is ok with sneak rank 3) and radicool you will be able to travel with so much weight even without those perks..
I would adjust switching 1 grade of Bandolier with 13 STR points and rank 3 of Enforcer with 13 AGI POINTS. Those 4 points needs to go 1 in LUCK to get grade 3 in Serendipity and 3 in END for Fireproof.
Since you are planning to use explosive weapons from short range (that’s how shotguns are supposed to be played) you will suffer from area damage. Fireproof is mandatory in this case as well as Serendipity grade 3.
The big lack in this build is Dodgy, wich is too useful in bloodied build to be ignored.
Best armor for this build would be wood honestly, but scout could be ok tho.